Part of the M60 has been closed since the crash this afternoon.
Emergency services have been called to Ashton under Lane at Junction 23 on Clip Road after the collision at 2 p.m.
Highways England says recovery vehicles are running.
It was not immediately clear how many vehicles were involved or if anyone was injured.
Monk Trophy tweeted: “Lane closure on M60C / WJ23 means you can’t turn right onto A635 Manchester RD. There is also a lane closure so there is less traffic.
“Police, fire, ambulance and traffic officers are attending.”
More updates will be posted in our live blog below.